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Lovastatin biosynthesis pathway and some of its biological activities

Polyketides are ubiquitous secondary metabolites generally products of microorganisms. They are very diverse and not involved in primary stage of reproduction or growth.

Polyketides are ubiquitous secondary metabolites generally products of microorganisms. They are very diverse and not involved in primary stage of reproduction or growth. Many interesting compounds of these groups are very well known such as rapamycin which is an immunosuppressant drug, lovastatin and many more. Lovastatin (C24H36O5) is one of the most widely prescribed medications because of its wide range in bioactivities. Lovastatin originated from a strain of Aspergillus terreus or monascus ruber through fermentation. Aspergillus terreus is the fungi commonly used for the production of this drug. Read More