In a publication in Molecular Metabolism, Danish researchers say that they have discovered a way to keep weight off while eating a high fat diet. To do this they genetically delete the enzyme NAMPT in fat tissue of mice, and such deletion renders the animals completely resistant to becoming overweight or obese, even on a very fatty diet. NAMPT is Nicotinamide phosphoribosyltransferase (NAmPRTase or Nampt) also known as pre-B-cell colony-enhancing factor 1(PBEF1) or visfatin is an enzyme that in humans is encoded by the NAMPT gene. Wikipedia
'We gave the mice a diet that more or less corresponds to continuously eating burgers and pizza. Still, it was impossible for them to expand their fat tissue. Our ultimate goal is that by understanding these fundamental underpinnings of how we become obese, we can apply our finding to the development of novel treatment strategies for metabolic disease,' says Karen Nørgaard Nielsen, first author on the publication and a Ph.D. student at the Novo Nordisk Foundation Center for Basic Metabolic Research. Read the publication here.
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